SH2-B Mouse, Unlabeled, Clone: 46, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611526
Receptor tyrosine kinase ligation induces autophosphorylation of tyrosine residues within the cytoplasmic region and activation of proteins containing Src homology 2 (SH2) domains, such as PLCγ, PI-3 kinase, Shc, and SH2-B. Three alternatively spliced isoforms of SH2-B (α, β, γ) function as tyrosine kinase receptor adaptor proteins. Although each contains an N-terminal pleckstrin homology (PH) domain and a C-terminal SH2 domain, they differ in their C-termini downstream of the SH2 domain. SH2-B isoforms are expressed in a variety of tissues, including brain, lung, muscle, kidney, heart, and ovary. In neurons, SH2-Bβ binds to TrkA, TrkB, and TrkC receptors and is a substrate for TrkA receptor-mediated phosphorylation. In PC12 cells, SH2-Bβ is phosphorylated at multiple Ser/Thr residues by kinases in the MEK/ERK cascade and is required for NGF-induced differentiation. Additionally, SH2-Bβ binds to activated insulin and PDGF receptors and binds to and acts as a substrate for JAK2 tyrosine kinase during growth hormone signaling. Thus, SH2-B proteins are important signaling molecules in tyrosine kinase receptor pathways, especially those mediating neuronal differentiation.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Rat SH2-Bβ, aa 403-513
Formula Weight [Chemical]: 100kDa
Immunofluorescence, Western Blotting
|Human, Murine, Rat|
|Immunofluorescence, Western Blot|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok