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SH2-B Mouse, Unlabeled, Clone: 46, BD

Catalog No. BDB611526 Shop All BD Biosciences Products
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BDB611526 50 μg
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Catalog No. BDB611526 Supplier BD Biosciences Supplier No. 611526

Description

Mouse Monoclonal Antibody

Receptor tyrosine kinase ligation induces autophosphorylation of tyrosine residues within the cytoplasmic region and activation of proteins containing Src homology 2 (SH2) domains, such as PLCγ, PI-3 kinase, Shc, and SH2-B. Three alternatively spliced isoforms of SH2-B (α, β, γ) function as tyrosine kinase receptor adaptor proteins. Although each contains an N-terminal pleckstrin homology (PH) domain and a C-terminal SH2 domain, they differ in their C-termini downstream of the SH2 domain. SH2-B isoforms are expressed in a variety of tissues, including brain, lung, muscle, kidney, heart, and ovary. In neurons, SH2-Bβ binds to TrkA, TrkB, and TrkC receptors and is a substrate for TrkA receptor-mediated phosphorylation. In PC12 cells, SH2-Bβ is phosphorylated at multiple Ser/Thr residues by kinases in the MEK/ERK cascade and is required for NGF-induced differentiation. Additionally, SH2-Bβ binds to activated insulin and PDGF receptors and binds to and acts as a substrate for JAK2 tyrosine kinase during growth hormone signaling. Thus, SH2-B proteins are important signaling molecules in tyrosine kinase receptor pathways, especially those mediating neuronal differentiation.

Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Human
Immunogen: Rat SH2-Bβ, aa 403-513
Formula Weight [Chemical]: 100kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen SH2-B
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 46
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Rat SH2-Bβ, aa 403-513
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Isotype IgG1
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