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SH2-B Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611526

Catalog No. BDB611526

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Receptor tyrosine kinase ligation induces autophosphorylation of tyrosine residues within the cytoplasmic region and activation of proteins containing Src homology 2 (SH2) domains, such as PLCγ, PI-3 kinase, Shc, and SH2-B. Three alternatively spliced isoforms of SH2-B (α, β, γ) function as tyrosine kinase receptor adaptor proteins. Although each contains an N-terminal pleckstrin homology (PH) domain and a C-terminal SH2 domain, they differ in their C-termini downstream of the SH2 domain. SH2-B isoforms are expressed in a variety of tissues, including brain, lung, muscle, kidney, heart, and ovary. In neurons, SH2-Bβ binds to TrkA, TrkB, and TrkC receptors and is a substrate for TrkA receptor-mediated phosphorylation. In PC12 cells, SH2-Bβ is phosphorylated at multiple Ser/Thr residues by kinases in the MEK/ERK cascade and is required for NGF-induced differentiation. Additionally, SH2-Bβ binds to activated insulin and PDGF receptors and binds to and acts as a substrate for JAK2 tyrosine kinase during growth hormone signaling. Thus, SH2-B proteins are important signaling molecules in tyrosine kinase receptor pathways, especially those mediating neuronal differentiation.

Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Human
Immunogen: Rat SH2-Bβ, aa 403-513
Formula Weight [Chemical]: 100kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

SH2-B
46
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Rat SH2-Bβ
50μg
Cell Biology
Monoclonal
Documents
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