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SH2 domain protein 1A, Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against a full-length human SH2D1A protein.

Supplier:  Abnova Corporation H00004068D01P

Catalog No. 89-017-822


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Description

Description

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP
Specifications

Specifications

SH2 domain protein 1A
Polyclonal
Rabbit polyclonal antibody raised against a full-length human SH2D1A protein.
SH2D1A
DSHP/EBVS/FLJ18687/FLJ92177/IMD5/LYP/MTCP1/SAP/XLP/XLPD
Rabbit
Affinity Purified
RUO
Primary
Human
Antibody
Western Blot
Unconjugated
PBS with no preservative; pH 7.4
NM_002351
SH2D1A
SH2D1A (NP_002342.1, 1 a.a. ∼ 128 a.a) full-length human protein.
100 μg
Membrane Receptors
4068
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
IgG
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