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SH2 domain protein 1A, Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against a full-length human SH2D1A protein.
Supplier: Abnova Corporation H00004068D01P
Description
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Sequence: MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAPSpecifications
SH2 domain protein 1A | |
Polyclonal | |
Rabbit polyclonal antibody raised against a full-length human SH2D1A protein. | |
SH2D1A | |
DSHP/EBVS/FLJ18687/FLJ92177/IMD5/LYP/MTCP1/SAP/XLP/XLPD | |
Rabbit | |
Affinity Purified | |
RUO | |
Primary | |
Human | |
Antibody |
Western Blot | |
Unconjugated | |
PBS with no preservative; pH 7.4 | |
NM_002351 | |
SH2D1A | |
SH2D1A (NP_002342.1, 1 a.a. ∼ 128 a.a) full-length human protein. | |
100 μg | |
Membrane Receptors | |
4068 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
IgG |
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