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SHP2 Mouse, Unlabeled, Clone: 79, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610621

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Catalog No. BDB610621


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Description

Description

SHP2 (also known as PTP1D, Syp, SHPTP2 and PTP2C) is a member of the cytosolic class of protein-tyrosine phosphatases (PTPs). SHP2 has been reported to contain two SH2 domains where both SH2 domains are N-terminal to the PTP catalytic domain. The expression of SHP2 has been reported to be highest in brain, heart, and kidney. The PTPs are thought to function with other protein-tyrosine kinases to maintain intracellular protein phosphotyrosine homeostasis and cell cycle progression. The presence ofSH2 domains in SHP2 (PTP1D) has prompted speculation that binding to specific phosphorylated tyrosine residues is key to its function. SHP2 (PTP1D) is tyrosine- phosphorylated and activated in response to stimulation with EGF or PDGF.

Specifications

Specifications

SHP2
79
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
PTP1D, Syp, SHPTP2 and PTP2C
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50μg
Cell Biology
Primary
Canine, Chicken, Frog, Human, Murine, Rat
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