MilliporeSigma anti-SIGIRR Clone: 3H8-2G3,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma ST1681200UL
Specifically detects SIGIRR Clone: 3H8-2G3 in Human samples, and it is validated for Immuno BlottingThe SIGIRR protein acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Its extracellular domain is known to interfere with the heterodimerization of Il1R1 and IL1RAP.
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|Recognizes the ∽32kDa SIGIRR protein in HepG2 cells.|
|Immuno Blotting, Immunoblot|
|Full-length, recombinant, human SIGIRR (aa 1-411), expressed as a GST fusion protein|
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