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Siglec-G Mouse anti-Mouse, Alexa Fluor 647, Clone: SH1, BD

Catalog No. BDB563336 Shop All BD Biosciences Products
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BDB563336 50 μg
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Catalog No. BDB563336 Supplier BD Biosciences Supplier No. 563336
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Description

Mouse Monoclonal Antibody

The SH1 monoclonal antibody specifically binds to mouse Siglec-G (sialic acid binding immunoglobulin-like lectin G), also known as Siglec10. Siglec-G is a Type I transmembrane glycoprotein that belongs to the Immunoglobulin superfamily. Siglec-G functions as an adhesion molecule that mediates sialic-acid dependent binding to cells. Siglec-G is expressed on cells of the B cell lineage. Siglec-G is most highly expressed by pre-B cells and B1a cells within the B cell lineage and is not detectable on T cells. Siglec-G can inhibit B cell receptor-mediated calcium signaling when it is overexpressed. Mice that lack Siglec-G have significantly increased numbers of B1a cells that begins early in development and is B cell intrinsic. Siglec-G-deficient mice have higher titers of natural IgM antibodies than their normal counterparts. Mouse Siglec-G is the ortholog of human Siglec-10 (also known as, CD330).

TRUSTED_SUSTAINABILITY

Specifications

Antigen Siglec-G
Applications Flow Cytometry
Classification Monoclonal
Clone SH1
Concentration 0.2mg/mL
Conjugate Alexa Fluor 647
Description Siglecg; mSiglec-G; Siglec10; Siglec 10; CD330
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse Extracellular Siglec-G Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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