SIGLEC6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA511677

Catalog No. PIPA511677

Description

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predomitly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Specifications

• Antigen: SIGLEC6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: O43699
• Gene Symbols: SIGLEC6
• Immunogen: KLH conjugated synthetic peptide between 10-40 amino acids from the N-terminal region of human SIGLEC6
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 0.46 mg/mL
• Gene: SIGLEC6
• Gene Alias: Sialic acid binding Ig-like lectin 6, Obesity-binding protein 1, OB-BP1, CD33 antigen-like 1, CD33L
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 946
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid