SIPA1L3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520849
A suggested positive control is SK-N-SH cell lysate. PA5-20849 can be used with blocking peptide PEP-0963.Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
|A 15 amino acid peptide from near the amino terminus of human SIPA1L3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|SPAL3; SIPA1-like protein 3; SPA-1-like 3; SPA-1-like protein 3; signal-induced proliferation-associated 1-like protein 3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|23094, 292771, 74206|
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