Learn More
SIRPα1 Mouse, Unlabeled, Clone: 27, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 611008
Description
Protein tyrosine phosphatases participate in the intracellular signaling pathways of mitosis, differentiation, migration, survival, transformation, and death. SHP-2, a SH-2 domain containing phosphotyrosine phosphatase, is a positive signal transducer of receptor tyrosine kinases (RTKs) and cytokine receptors. SIRPs (Signal-Regulatory Proteins) were identified as a result of their association with SHP-2. The 15+ members of this family consist of two subtypes based on the presence or absence of a cytoplasmic SHP-2-binding domain. SIRPα1 is a transmembrane polypeptide substrate of activated RTKs. When tyrosine-phosphorylated, SIRPα1 binds SHP-2, SHP-1, Grb2 through an SH2 interaction. The SIRP proteins also constitute a subfamily within the Ig superfamily because they contain transmembrane glycoproteins with three Ig-like extracellular domains. Additionally, SIRPs' cytoplasmic tails contain two ITI (immunoreceptor tyrosine-based inhibition motifs). Although SIRPs have been shown to inhibit signaling through RTKs, their function is yet to be determined.
Immunofluorescence, Western Blotting

Specifications
SIRPα1 | |
Monoclonal | |
250μg/mL | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
IgG1 |
Immunofluorescence, Western Blot | |
27 | |
Unconjugated | |
Human SIRPα1 aa. 395-503 | |
50 μg | |
Cell Biology | |
Mouse, Rat |
Your input is important to us. Please complete this form to provide feedback related to the content on this product.