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SIRPα1 Mouse, Unlabeled, Clone: 27, BD

Catalog No. BDB611008 Shop All BD Biosciences Products
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BDB611008 50 μg
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Catalog No. BDB611008 Supplier BD Biosciences Supplier No. 611008

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

Protein tyrosine phosphatases participate in the intracellular signaling pathways of mitosis, differentiation, migration, survival, transformation, and death. SHP-2, a SH-2 domain containing phosphotyrosine phosphatase, is a positive signal transducer of receptor tyrosine kinases (RTKs) and cytokine receptors. SIRPs (Signal-Regulatory Proteins) were identified as a result of their association with SHP-2. The 15+ members of this family consist of two subtypes based on the presence or absence of a cytoplasmic SHP-2-binding domain. SIRPα1 is a transmembrane polypeptide substrate of activated RTKs. When tyrosine-phosphorylated, SIRPα1 binds SHP-2, SHP-1, Grb2 through an SH2 interaction. The SIRP proteins also constitute a subfamily within the Ig superfamily because they contain transmembrane glycoproteins with three Ig-like extracellular domains. Additionally, SIRPs' cytoplasmic tails contain two ITI (immunoreceptor tyrosine-based inhibition motifs). Although SIRPs have been shown to inhibit signaling through RTKs, their function is yet to be determined.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen SIRPα1
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 27
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human SIRPα1 aa. 395-503
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse, Rat
Isotype IgG1
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