SIRPα1 Mouse, Unlabeled, Clone: 27, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611008

Catalog No. BDB611008

Description

Protein tyrosine phosphatases participate in the intracellular signaling pathways of mitosis, differentiation, migration, survival, transformation, and death. SHP-2, a SH-2 domain containing phosphotyrosine phosphatase, is a positive signal transducer of receptor tyrosine kinases (RTKs) and cytokine receptors. SIRPs (Signal-Regulatory Proteins) were identified as a result of their association with SHP-2. The 15+ members of this family consist of two subtypes based on the presence or absence of a cytoplasmic SHP-2-binding domain. SIRPα1 is a transmembrane polypeptide substrate of activated RTKs. When tyrosine-phosphorylated, SIRPα1 binds SHP-2, SHP-1, Grb2 through an SH2 interaction. The SIRP proteins also constitute a subfamily within the Ig superfamily because they contain transmembrane glycoproteins with three Ig-like extracellular domains. Additionally, SIRPs' cytoplasmic tails contain two ITI (immunoreceptor tyrosine-based inhibition motifs). Although SIRPs have been shown to inhibit signaling through RTKs, their function is yet to be determined.

Immunofluorescence, Western Blotting

Specifications

• Antigen: SIRPα1
• Clone: 27
• Conjugate: Unconjugated
• Host Species: Murine
• Isotype: IgG₁
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine, Rat

• Applications: Immunofluorescence, Western Blot
• Concentration: 250μg/mL
• Format: Affinity Purified
• Immunogen: Human SIRPα1 aa. 395-503
• Quantity: 50μg
• Research Discipline: Cell Biology
• Monoclonal or Polyclonal: Monoclonal