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SIRPα1 Mouse, Unlabeled, Clone: 27, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611008

Catalog No. BDB611008

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Protein tyrosine phosphatases participate in the intracellular signaling pathways of mitosis, differentiation, migration, survival, transformation, and death. SHP-2, a SH-2 domain containing phosphotyrosine phosphatase, is a positive signal transducer of receptor tyrosine kinases (RTKs) and cytokine receptors. SIRPs (Signal-Regulatory Proteins) were identified as a result of their association with SHP-2. The 15+ members of this family consist of two subtypes based on the presence or absence of a cytoplasmic SHP-2-binding domain. SIRPα1 is a transmembrane polypeptide substrate of activated RTKs. When tyrosine-phosphorylated, SIRPα1 binds SHP-2, SHP-1, Grb2 through an SH2 interaction. The SIRP proteins also constitute a subfamily within the Ig superfamily because they contain transmembrane glycoproteins with three Ig-like extracellular domains. Additionally, SIRPs' cytoplasmic tails contain two ITI (immunoreceptor tyrosine-based inhibition motifs). Although SIRPs have been shown to inhibit signaling through RTKs, their function is yet to be determined.

Immunofluorescence, Western Blotting



Murine, Rat
Immunofluorescence, Western Blot
Affinity Purified
Human SIRPα1 aa. 395-503
Cell Biology
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