SLPI Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520386
A suggested positive control is A-20 cell lysate. PA5-20386 can be used with blocking peptide PEP-0503.Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kappa-B activation by inhibiting Ikappa-B degradation in the cytoplasm and competing for NF-kappa-B binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
|A 17 amino acid peptide from near the center of mouse SLPI.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|RP23-462O16.7; ALP; antileukoproteinase; secretory leukocyte protease inhibitor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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