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Description
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]
Specifications
Specifications
| Antigen | SNCA |
| Applications | ELISA, Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Clone | 2E4 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against a partial recombinant SNCA. |
| Formulation | PBS with no preservative; pH 7.4 |
| Gene | SNCA |
| Gene Accession No. | NM_000345 |
| Gene Alias | MGC110988/NACP/PARK1/PARK4/PD1 |
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