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SNX2 Mouse, Unlabeled, Clone: 13, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611308

Catalog No. BDB611308


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Description

Description

Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX)
domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1 directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1, SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX2 and other sorting nexins are thought to play important roles in the specificity of protein trafficking to and from the plasma membrane.

Host Species: Mouse
Clone: 13
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human SNX2 aa. 15-137
Formula Weight [Chemical]: 72kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

SNX2
13
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Sorting Nexin-2
Affinity Purified
Human SNX2 aa. 15-137
50μg
Cell Biology
Primary
Canine, Human
Documents
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