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SOD Mouse anti-Human, Unlabeled, Clone: G215-1, BD

Catalog No. BDB556360 Shop All BD Biosciences Products
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BDB556360 0.1 mg
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Catalog No. BDB556360 Supplier BD Biosciences Supplier No. 556360

Description

Mouse Monoclonal Antibody

The superoxide free radical O2.- is an intermediate form of molecular oxygen that is produced as a natural by-product of respiration and other biological processes Free radicals like O2.- can lead to the formation of additional reactive oxygen species that, in turn, can cause oxidative damage to DNA, protein, and lipid. The superoxide dismutases provide a defense against the damaging effects of O2.- by converting it to O2 + H2O2 (hydrogen peroxide). Hydrogen peroxide is then normally converted to water by either glutathione peroxidase or catalase. SODs are divided up into three types, and thought to evolve from two independent evolutionary lines: The copper- and zinc-containing SOD, CuZnSOD, is expressed in the cytosol of eukaryotic cells; the manganese-containing SOD, MnSOD, is present in bacteria, in the matrix of bacteria, and in mitochondria; and the iron-containing SOD, FeSOD, is found primarily in bacteria and is also expressed in some plants. All of the SODs catalyze the dismutation of O2.- at approximately the same rates. CuZnSOD lacks amino acid sequence homology with MnSOD and FeSOD, suggesting that it evolved independently from the FeSOD/MnSOD family of enzymes. Mutations have been described in the gene encoding CuZnSOD (SOD1) which reduce the activity and halflife of the enzyme. However, the role of these mutations in pathogenesis remains to be elucidated. Clone G215-1 recognizes human CuZnSOD. The antibody was originally characterized by western blot analysis of cells from transgenic mice expressing human CuZnSOD. Recombinant full-length human CuZnSOD GST fusion protein was used as immunogen.

Host Species: Mouse
Clone: G215-1
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Recombinant Human CuZnSOD GST Fusion Protein

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen SOD
Applications Western Blot
Classification Monoclonal
Clone G215-1
Concentration 0.5mg/mL
Conjugate Unconjugated
Description CuZnSOD Copper/Zinc-Binding Superoxide Dismutase
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant Human CuZnSOD GST Fusion Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2a
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For Research Use Only.

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