SPAM1, Rabbit, Monoclonal Antibody, Abnova™

Catalog No.	Quantity
89-200-111	1 mg x up to 3 Abs

Catalog No. 89-200-111 Supplier Abnova Corporation Supplier No. H00006677K

Description

Includes

Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Rabbit monoclonal antibody raised against a human SPAM1 peptide using ARM Technology.

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: SPAM1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Concentration: 1mg
• Conjugate: Unconjugated
• Description: sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
• Formulation: In 1X PBS, pH 7.4
• Gene: SPAM1
• Gene Accession No.: SPAM1
• Gene Alias: HYA1, HYAL1, HYAL3, HYAL5, MGC26532, PH-20, PH20, SPAG15
• Gene Symbols: SPAM1
• Host Species: Rabbit
• Immunogen: A synthetic peptide of human SPAM1
• Quantity: 1 mg x up to 3 Abs
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6677
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG