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sphingosine kinase 1, Mouse, Clone: 1D6, Abnova™

Catalog No. 89014230 Shop All Abnova Corporation Products
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89-014-230 100 μg
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Catalog No. 89-014-230 Supplier Abnova Corporation Supplier No. H00008877M01
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Description

Mouse monoclonal antibody raised against a full-length recombinant SPHK1.

Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM

Sequence: MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLLLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL

Specifications

Antigen sphingosine kinase 1
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1D6
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a full length recombinant SPHK1.
Formulation PBS with no preservative; pH 7.4
Gene SPHK1
Gene Accession No. BC008040
Gene Alias SPHK
Gene Symbols SPHK1
Host Species Mouse
Immunogen SPHK1 (AAH08040, 1 a.a. ∼ 384 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Endocrine/Metabolism
Primary or Secondary Primary
Gene ID (Entrez) 8877
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Isotype IgG2a κ
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