Learn More
Description
The MC631 monoclonal antibody reacts with Stage-Specific Embryonic Antigen-3 (SSEA-3), a carbohydrate epitope on the major ganglioside, but not the neutral glycolipid, of mouse embryos and human teratocarcinoma cells. As its name implies, the expression of SSEA-3 is stage-specific and can be used to characterize embryonic cells and monitor their differentiation. However, its expression pattern differs in the human and mouse. In the human, SSEA-3 is found on teratocarcinoma (embryonal carcinoma or EC), embryonic inner cell mass (ICM), and embryonic stem (ES) cells, and erythrocytes. As human stem cells undergo differentiation, SSEA-3 expression diminishes. In the mouse, SSEA-3 is found on oocytes, ova, zygotes, early cleavage-stage embryos, early blastocysts, ICM, primitive endoderm, and adult kidney, but not on EC or ES cells.
Host Species: Rat
Clone: MC631
Isotype: IgM
Species Reactivity: Human
Immunogen: Mouse Embryos
Flow Cytometry
Specifications
Specifications
| Antigen | SSEA-3 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | MC631 |
| Conjugate | FITC |
| Formulation | Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. |
| Host Species | Rat |
| Immunogen | Mouse Embryos |
| Purification Method | Affinity Purified |
| Quantity | 100 Tests |
| Show More |
Safety and Handling
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.