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ST2 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523316

Catalog No. PIPA523316


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Description

Description

ST2 is a member of the interleukin 1 receptor family. Studies of ST2 in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. ST2 belongs to the interleukin-1 receptor family with three Ig-like C2-type (immunoglobulin-like) domains and a TIR domain. ST2 is a receptor for interleukin-33 (IL-33) which upon stimulation recruits the signaling molecules MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Reports also suggest its possible role in helper T-cell function as well as in cell growth. Three isoforms of ST2 have been reported where isoform C is a membrane form and isoform B is a secreted form. ST2 may be induced by proinflammatory stimuli, and may also be found in serum of autoimmune disease. Different isoforms are restricted to different tissues while high expression of this protein is evident in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine.
Specifications

Specifications

ST2
Polyclonal
Unconjugated
IL1RL1
Liquid
IL1RL1
Synthetic peptide (36 CPRQGKPSYTVDWYYSQT 53) of ST2/IL1RL1 protein.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
Q01638, P14719, Q62611
DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-related protein, interleukin-1 receptor-like 1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
17082, 25556, 9173
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