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STAT1 Mouse anti-Human, Mouse, Clone: SM1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119323

Catalog No. 01-676-079


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Description

Description

This antibody recognizes an epitope included within amino acids 721-733 of STAT1.

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
Specifications

Specifications

STAT1
Monoclonal
Unconjugated
STAT1
Liquid
STAT1
STAT1 peptide sequence 721-733 (DNLLPMSPEEFDE).
Protein A
RUO
Antibody
Monoclonal
Human, Mouse
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
SM1
PBS with 15mM sodium azide; pH 7.4
P42224, P42225
DKFZp686B04100, ISGF-3, STAT91
Mouse
IgG2b
100 μg
4° C, do not freeze
Primary
20846, 6772
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