Stat1 Mouse, PE, Clone: 4a, BD

Catalog No.	Quantity
BDB562069	250 Tests

Catalog No. BDB562069 Supplier BD Biosciences Supplier No. 562069

Description

Mouse Monoclonal Antibody

STAT (Signal transducer and activator of transcription)nterferon- S timulated G ene F actor 3 ) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1α and 84-kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs).

The 4a monoclonal antibody recognizes the phosphorylated Y701 in Stat1 α.

Specifications

• Antigen: Stat1
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 4a
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Phosphorylated Human Stat1 Peptide
• Purification Method: Affinity Purified
• Quantity: 250 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2a