Stat2 (pY690) Mouse anti-Human, Unlabeled, Clone: 7A/STAT2 (PY690), BD

Catalog No.	Quantity
BDB558095	0.1 mg

Catalog No. BDB558095 Supplier BD Biosciences Supplier No. 558095

Description

Mouse Monoclonal Antibody

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat2 is a 113kDa protein having approximately 40% homology with Stat1a. Stat2 interacts with Stat1 for the efficient activation of Stat1 in response to IFN-α, which is essential for normal transcriptional activity of the ISGF3 complex. Stat2 phosphorylation at the tyrosine 690 residue (Y690) after IFN-α activation can occur independently of Stat1, but the localization and nuclear stability of phosphorylated Stat2 is dependent on Stat1. The 7a/Stat2 monoclonal antibody recognizes the phosphorylated Y690 of human Stat2.

Host Species: Mouse
Clone: 7a
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human Stat2 Peptide

Western Blotting

Specifications

• Antigen: Stat2 (pY690)
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 7A/STAT2 (PY690)
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Phosphorylated Human Stat2 Peptide
• Purification Method: Affinity Purified
• Quantity: 0.1 mg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.