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Stat4 (pY693) Mouse, Alexa Fluor 488, Clone: 38/P-STAT4, BD

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Catalog No. BDB558136 Supplier BD Biosciences Supplier No. 558136
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Description

Mouse Monoclonal Antibody

The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNγ in response to treatment with IL-12. IFNγ plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 38
Isotype: IgG2b κ
Species Reactivity: Human, Mouse
Immunogen: Phosphorylated Human Stat4 (pY693)

Flow Cytometry, Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen Stat4 (pY693)
Applications Flow Cytometry
Classification Monoclonal
Clone 38/P-STAT4
Conjugate Alexa Fluor 488
Description Signal transducer and activator of transcription 4; SLEB11
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human Stat4 (pY693)
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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For Research Use Only.

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