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Stat5 Mouse, Unlabeled, Clone: 89, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen Stat5
Isotype IgG2b
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610191
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BD Biosciences
610191
50μg
Each for $232.00
Add to cart
 
BDB610192
View Documents
BD Biosciences
610192
150μg
Each for $458.00
Add to cart
 
Description

Description

Stat5, also known as mammary gland factor (MGF) has been shown to play a critical role in the lactogenic hormone response and has been well characterized in mammary epithelial cells. The SH3 domain of MGF shows extensive homology with the SH2 domains of Stat1 and Stat2. This homology has led to its classification as a member of the Stat family. The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment and activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Stat5a has been shown to be involved in lactogenesis and mammary development, while Stat5b has been shown to be involved in growth hormone signaling and to play a role in liver gene expression. Stat5 activity is tightly regulated throughout gestation, lactation, and post-lactation.

Specifications

Specifications

Stat5
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
MGF
IgG2b
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
89
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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