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Description
Includes
Up to three rabbit IgG clones of 1mg each will be delivered to customer.
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq]
Expression: Overexpression vector and transfection into 293H cell line
Order Info
- Customer may provide cell or tissue lysate for antibody screening.
- Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
Specifications
Specifications
| Antigen | STRADA |
| Applications | ELISA, Western Blot |
| Classification | Monoclonal |
| Concentration | 1mg |
| Conjugate | Unconjugated |
| Description | STE20-related kinase adaptor alpha |
| Formulation | In 1X PBS, pH 7.4 |
| Gene | STRADA |
| Gene Accession No. | STRADA |
| Gene Alias | FLJ90524, LYK5, NY-BR-96, PMSE, STRAD, Stlk |
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