STRAP Mouse, Unlabeled, Clone: 22, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611346
The transforming growth factor β (TGF-β) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-β receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-β to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thr receptor associated protein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-βI and TGF-βII receptors and overexpression of STRAP leads to inhibition of TGF-β-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-β signal transduction pathways in a variety of tissues and species.
Host Species: Mouse
Species Reactivity: Rat
Immunogen: Mouse STRAP aa. 42-154
Formula Weight [Chemical]: 39kDa
Immunofluorescence, Western Blotting
|Mouse STRAP aa. 42-154|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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