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MilliporeSigma™ anti-Synapsin-1 Clone: MEGS3-10A,
Mouse Monoclonal Antibody
Supplier: MilliporeSigma™ MABN1847
Description
Specifically detects Synapsin-1 Clone: MEGS3-10A in Mouse samples, and it is validated for Immunocytochemistry, Western Blotting
Synapsin-1 (UniProt O88935; also known as Synapsin I) is encoded by the Syn1 (also known as Syn-1) gene (Gene ID 20964) in murine species. The synapins constitute a family of abundant neuronal phosphoproteins that regulate SV trafficking and neurotransmitter release at the pre-synaptic terminal. Three genes exisit in mammals, encoding altogether 11 synapsin members by alternative splicings (Synapsin Ia & Ib by SYN1, Synapsin IIa & IIb by SYN2, Synapsin IIIa through IIIf by SYN3), Syn III is the most precociously expressed isoform that has a role in the early phases of neural development and is downregulated in mature neurons. On the other hand, Syn I and Syn II are expressed at low levels at birth and their expressions progressively increase during synaptogenesis to reach a stable plateau at 1-2 months of life. The NH2-terminal region is divided in A, B, and C domains and is highly conserved among synapsin isoforms. Synapsins are regulated by postransloational phosphorylations. Domain A contains PKA and CaMKI/IV phosphorylation sites, domain B contains MAPK/Erk phosphorylation sites, and domain C is phosphorylated by Src. The c-terminal regions contain spliced domains and diverge among synapsin isoforms (domain D in Syn Ia and Ib, domain G in Syn Iia and Iib, domain H in Syn Iia, and domain J in Syn IIIa), although they all bear proline-rich regions binding to several SH3-containing proteins and additional phosphorylation sites for CaMKII, MAPK/Erk, and cdk1/5.
Specifications
Synapsin-1 | |
Monoclonal | |
Unconjugated | |
O88935 | |
Mouse | |
Purified by ion-exchange chromatography | |
RUO | |
Primary | |
Mouse | |
Purified |
Immunocytochemistry, Western Blot | |
MEGS3-10A | |
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide. | |
Syn1, Syn-1 | |
Recombinant full-length mouse synapsin-1. | |
100 μL | |
Neuroscience | |
NP_038708.3 | |
2°C to 8°C for one year from date of shipment | |
IgG2b κ |
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