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MilliporeSigma™ anti-Synapsin-2 Clone: 19.21,

Catalog No. MABN1584MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN1584MI 100 μg Unconjugated
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Catalog No. MABN1584MI Supplier MilliporeSigma™ Supplier No. MABN1584
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Description

Mouse Monoclonal Antibody

Specifically detects Synapsin-2 Clone: 19.21 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Synapsin-2 (UniProt Q63537; also known as Synapsin II) is encoded by the Syn2 gene (Gene ID 29179) in rat species. The synapins constitute a family of abundant neuronal phosphoproteins that regulate SV trafficking and neurotransmitter release at the pre-synaptic terminal. Three genes exisit in mammals, encoding altogether 11 synapsin members by alternative splicings (Synapsin Ia & Ib by SYN1, Synapsin IIa & IIb by SYN2, Synapsin IIIa through IIIf by SYN3), Syn III is the most precociously expressed isoform that has a role in the early phases of neural development and is downregulated in mature neurons. On the other hand, Syn I and Syn II are expressed at low levels at birth and their expressions progressively increase during synaptogenesis to reach a stable plateau at 1-2 months of life. The NH2-terminal region is divided in A, B, and C domains and is highly conserved among synapsin isoforms. Synapsins are regulated by postransloational phosphorylations. Domain A contains PKA and CaMKI/IV phosphorylation sites, domain B contains MAPK/Erk phosphorylation sites, and domain C is phosphorylated by Src. The c-terminal regions contain spliced domains and diverge among synapsin isoforms (domain D in Syn Ia and Ib, domain G in Syn Iia and Iib, domain H in Syn Iia, and domain J in Syn IIIa), although they all bear proline-rich regions binding to several SH3-containing proteins and additional phosphorylation sites for CaMKII, MAPK/Erk, and cdk1/5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Synapsin-2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 19.21
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q63537
Gene Symbols Syn2
Host Species Mouse
Immunogen Purified recombinant rat synapsin-2.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_001029192
Test Specificity Clone 19.21 reacts with both synapsin-2 spliced isoforms (IIa and IIb). Clone 19.21 does not react with any of the two synapsin-1 spliced isoforms (Vaccaro, P., et al. (1997). Brain Res. Mol. Brain Res. 52(1):1-16).
Target Species Human, Mouse, Rat
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2a κ
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