Syntaxin 1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA11042

Catalog No. PA11042

Description

PA1-1042 detects Syntaxin 1 in rat, mouse and bovine samples. PA1-1042 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ∽33 kDa protein representing Syntaxin 1 in rat, mouse and bovine brain tissue samples. The PA1-1042 immunogen is a synthetic peptide corresponding to residues V(22) T V D R D R F M D E F F E Q V E E I R(41) of rat Syntaxin 1. This sequence is conserved in mouse, human and bovine. The PA1-1042 immunizing peptide (Cat. No. PEP-278) is available for use in neutralization and control experiments.

Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release. Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex. Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.

Specifications

• Antigen: Syntaxin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STX1A
• Gene Alias: HPC-1, P35-1, STX1, SYN1A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116470, 20907, 6804, 788566
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P32850, Q16623, O35526, P32851
• Gene Symbols: STX1A
• Immunogen: Synthetic peptide corresponding to residues V(22) T V D R D R F M D E F F E Q V E E I R(41) of rat Syntaxin 1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Bovine, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG