MilliporeSigma anti-TACE (807 - 823), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC491100UG
Specifically detects TACE (807 - 823) Clone: in Human, Mouse, Rat samples, and it is validated for Immuno BlottingTumor-necrosis factor-α is a proinflammatory cytokine that contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α. TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE, a~130kDa protein, is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFα, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
|TACE (807 - 823)|
|a synthetic peptide (ASFKLQRQNRVDSKETE) corresponding to amino acids 807-823 of human TACE|
|Human, Murine, Rat|
|Immuno Blotting, Immunoblot|
|Recognizes the ∽130kDa TACE protein in HeLa and Jurkat cells.|
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