Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-TACE (807 - 823), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC491100UG

Catalog No. PC491100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects TACE (807 - 823) Clone: in Human, Mouse, Rat samples, and it is validated for Immuno Blotting

Tumor-necrosis factor-α is a proinflammatory cytokine that contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α. TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE, a~130kDa protein, is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFα, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
Specifications

Specifications

TACE (807 - 823)
Unconjugated
purified
a synthetic peptide (ASFKLQRQNRVDSKETE) corresponding to amino acids 807-823 of human TACE
100μg
−20°C
Polyclonal
Human, Murine, Rat
Immuno Blotting, Immunoblot
In PBS.
Rabbit
IgG
RUO
Primary
Recognizes the ∽130kDa TACE protein in HeLa and Jurkat cells.
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only