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MilliporeSigma™ anti-TACE (807 - 823), Polyclonal

Catalog No. PC491100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
PC491100UG 100 μg Unconjugated
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Catalog No. PC491100UG Supplier MilliporeSigma™ Supplier No. PC491100UG

Description

Rabbit Polyclonal Antibody

Specifically detects TACE (807 - 823) Clone: in Human, Mouse, Rat samples, and it is validated for Immuno Blotting

Tumor-necrosis factor-α is a proinflammatory cytokine that contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α. TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE, a∽130kDa protein, is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFα, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TACE (807 - 823)
Applications Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In PBS.
Host Species Rabbit
Immunogen a synthetic peptide (ASFKLQRQNRVDSKETE) corresponding to amino acids 807-823 of human TACE
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽130kDa TACE protein in HeLa and Jurkat cells.
Target Species Human, Mouse, Rat
Content And Storage −20°C
Form Purified
Isotype IgG
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