MilliporeSigma™ anti-TACE (807 - 823), Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ PC491100UG

Catalog No. PC491100UG

Description

Specifically detects TACE (807 - 823) Clone: in Human, Mouse, Rat samples, and it is validated for Immuno Blotting

Tumor-necrosis factor-α is a proinflammatory cytokine that contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α. TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE, a∽130kDa protein, is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFα, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.

Specifications

• Antigen: TACE (807 - 823)
• Classification: Polyclonal
• Formulation: In PBS.
• Immunogen: a synthetic peptide (ASFKLQRQNRVDSKETE) corresponding to amino acids 807-823 of human TACE
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽130kDa TACE protein in HeLa and Jurkat cells.
• Content And Storage: −20°C
• Isotype: IgG

• Applications: Immunoblot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Purified

For Research Use Only