TAB3 Rabbit anti-Canine, Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141489
DescriptionTAB3, a member of RNA polymerase beta chain family is a 712 aa, intracellular protein that acts as adaptors linking TAK1 binding proteins. This protein is known to function redundantly as mediator of TAK1 activation in response to various stimuli and is critical for both IL-1 and TNF-induced activation of the NF-kB signal transduction pathway. When overexpressed, TAB3 activates both NF-kB and AP-1 transcription factors. When stimulated by the pro-inflammatory cytokines, protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complex. It is also known to function as DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA.
|Synthetic peptide corresponding to residues 50-100 of human TAB3.|
|Canine, Human, Mouse|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|257397, 491807, 66724|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok