TAP Mouse, Unlabeled, Clone: 19, BD

Catalog No.	Quantity
BDB611580	50 μg

Catalog No. BDB611580 Supplier BD Biosciences Supplier No. 611580

Description

Mouse Monoclonal Antibody

Nuclear export of cellular mRNAs is highly selective, wherein only fully processed RNAs are exported. Retroviral replication requires export of unspliced viral RNAs, which serve as templates for structural proteins and as genomic RNA for progeny virus. The export of unspliced viral RNA depends on the interaction of cis-acting RNA elements with cellular factors. In simian type D retroviruses, the cis-acting element is the constitutive transport element (CTE). CTE-dependent nuclear transport is mediated by the cellular TAP protein. TAP (Tip associating protein) is the vertebrate homolog of the yeast nuclear export protein Mex67p. TAP is a nuclear protein that shuttles between the nucleus and cytoplasm. It contains an N-terminal nuclear localization and export region (NLS-NES), a central RNA binding domain (RBD), and a C-terminal portion that is required for nuclear localization and nuclear rim association. The first 372 aa of TAP are necessary and sufficient for binding and nuclear export of CTE-containing RNA. Thus, TAP contains a novel RNA-binding motif that recognizes CTE-containing RNA and interacts with other components of the nuclear transport machinery.

Specifications

• Antigen: TAP
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 19
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Description: Manganese Superoxide Dismutase
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human TAP aa. 488-596
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1