MilliporeSigma™ anti-Tau Clone: Tau-2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MAB375C

Catalog No. MAB375CMI

Description

Specifically detects Tau Clone: Tau-2 in Human, Rat samples, and it is validated for Immunohistochemistry

Microtubule-associated protein tau (UniProt P29172; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU) gene (Gene ID 281296) in bovine species. Extracellular plaque deposits composed of amyloid-β and intracellular neurofibrillary tangles (NFTs) composed of truncated and hyperphosphorylated tau are two neuropathological hallmarks of Alzheimer's disease (AD). Tau pathology (tauopathy) can cause toxicity when the brain is devoid of amyloid plaques, and tangle pathology correlates better with clinical dementia than amyloid pathology. Abnormal processing of tau by hyperphosphorylation and proteolytic truncation contribute to the toxicity of tau. Tau is known to be cleaved by various proteases, including caspases, calpains, cathepsins, thrombin, and puromycin-sensitive aminopeptidase, as well as the lysosomal cysteine proteinase asparagine endopeptidase (AEP). MAPK, GSK-3, and Cdk-5 are three known kinases that target various tau phosphorylation sites. Tau also undergoes other types of posttranslational modifications, including glycosylation, ubiquitination, glycation, polyamination, nitration, and lysine methylation, which are believed to be important for its non-pathological functions, including polymerization and stabilization of microtubules.

Specifications

• Antigen: Tau
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: P29172
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Tau from bovine, feline and abnormal human tau in Alzheimer's disease.
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG1 κ

• Applications: Immunohistochemistry
• Clone: Tau-2
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: MAPT, TAU
• Immunogen: Bovine Tau.
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_776531
• Target Species: Human, Rat
• Form: Purified

For Research Use Only