MilliporeSigma™ anti-Tau Clone: Tau-2,

Catalog No.	Quantity	Conjugate
MAB375CMI	100 μg	Unconjugated

Catalog No. MAB375CMI Supplier MilliporeSigma™ Supplier No. MAB375C

Description

Mouse Monoclonal Antibody

Specifically detects Tau Clone: Tau-2 in Human, Rat samples, and it is validated for Immunohistochemistry

Microtubule-associated protein tau (UniProt P29172; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU) gene (Gene ID 281296) in bovine species. Extracellular plaque deposits composed of amyloid-β and intracellular neurofibrillary tangles (NFTs) composed of truncated and hyperphosphorylated tau are two neuropathological hallmarks of Alzheimer's disease (AD). Tau pathology (tauopathy) can cause toxicity when the brain is devoid of amyloid plaques, and tangle pathology correlates better with clinical dementia than amyloid pathology. Abnormal processing of tau by hyperphosphorylation and proteolytic truncation contribute to the toxicity of tau. Tau is known to be cleaved by various proteases, including caspases, calpains, cathepsins, thrombin, and puromycin-sensitive aminopeptidase, as well as the lysosomal cysteine proteinase asparagine endopeptidase (AEP). MAPK, GSK-3, and Cdk-5 are three known kinases that target various tau phosphorylation sites. Tau also undergoes other types of posttranslational modifications, including glycosylation, ubiquitination, glycation, polyamination, nitration, and lysine methylation, which are believed to be important for its non-pathological functions, including polymerization and stabilization of microtubules.

Specifications

• Antigen: Tau
• Applications: Immunohistochemistry
• Classification: Monoclonal
• Clone: Tau-2
• Conjugate: Unconjugated
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P29172
• Gene Symbols: MAPT, TAU
• Host Species: Mouse
• Immunogen: Bovine Tau.
• Purification Method: Protein G purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_776531
• Test Specificity: Tau from bovine, feline and abnormal human tau in Alzheimer's disease.
• Target Species: Human, Rat
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only