MilliporeSigma™ anti-Tau Clone: TAU-5

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ 577801100UG

Catalog No. 57-780-1100UG

Description

Specifically detects Tau Clone: TAU-5 in Human, Mouse, Rat, Sheep samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting

Tau is a neuronal microtubule-associated protein found predominantly in axons. Tau promotes tubulin polymerization and stabilizes microtubules, and it links certain signaling pathways to the cytoskeleton. Hyperphosphorylated tau is the major component of paired helical filaments, the building block of neurofibrillary lesions in Alzheimer’s disease. Hyperphosphorylation impairs the microtubule-binding function of tau, resulting in the destabilization of microtubules, and ultimately leading to degeneration of the affected neurons.

Specifications

• Antigen: Tau
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Sheep
• Form: Purified

• Applications: Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: TAU-5
• Formulation: In PBS.
• Immunogen: purified bovine microtubule-associated proteins
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽45-68kDa Tau protein.
• Content And Storage: ≤ -70°C
• Isotype: IgG1

For Research Use Only