beta Tubulin Rabbit anti-Human, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA526039

Catalog No. PIPA526039

Description

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintece. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules. Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.

Specifications

• Antigen: beta Tubulin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: M0R8B6, Q9H4B7, A2AQ07
• Gene Symbols: TUBB1
• Immunogen: human TBB1 recombit protein.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Gene: TUBB1
• Gene Alias: beta tubulin 1, class VI, class VI beta-tubulin, tubulin beta-1 chain
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81027, 679312, 545486
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid