MilliporeSigma™ anti-TBK1 Clone: 108A429,

Catalog No.	Quantity	Conjugate
AM76100UG	100 μg	Unconjugated

Catalog No. AM76100UG Supplier MilliporeSigma™ Supplier No. AM76100UG

Description

Mouse Monoclonal Antibody

Specifically detects TBK1 Clone: 108A429 in Human samples, and it is validated for Immuno Blotting

Nuclear factor κB (NF-κB) is sequestered in cell cytoplasm by the IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB, preventing its translocation to the nucleus. Stimulus by tumor necrosis factor or other cytokines results in the phosphorylation and degradation of IκB, releasing NF-κB dimers. These dimers then translocate to the nucleus and activate target genes. IκBα synthesis is autoregulated. IκB proteins are phosphorylated by an IκB kinase made up of at least three proteins; IKK1/α, IKK2/β, and IKK3/γ. IKK 1/α and IKK2/β are phosphorylated by NF-κB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1) respectively. TANK-binding kinase (TBK1) has recently been identified as a member of the IKK family. TRAF-associated NF-κB activator (TANK) interacts with TBK1 and activates NF-κB in a kinase-dependent manner.

Specifications

• Antigen: TBK1
• Applications: Immunoblot
• Classification: Monoclonal
• Clone: 108A429
• Conjugate: Unconjugated
• Formulation: In PBS, 0.2% gelatin.
• Host Species: Mouse
• Immunogen: full-length, recombinant, human TBK1 fused to a His·Tag™ sequence
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽80kDa TBK1 protein in HEK293 cells.
• Target Species: Human
• Content And Storage: −20°C
• Form: Purified
• Isotype: IgG1

For Research Use Only