TCF-7/TCF-1 Mouse, PE, Clone: S33-966, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564217
The S33-966 monoclonal antibody specifically binds to TCF-7 (Transcription factor 7) which is also known as TCF-1 (T-cell factor 1). TCF-7 is a member of the High Mobility Group (HMG) DNA binding protein family of transcription factors. TCF-7 is expressed in thymocytes, T lymphocytes and proliferating epithelial cells. TCF-7 is expressed in the earliest T cell precursors and serves as a critical transcriptional regulator that is involved in the differentiation of thymocytes to become mature T lymphocytes. TCF-7 is necessary for the survival of immature CD4+CD8+ thymocytes. TCF-7 can also promote the differentiation of mature peripheral T cells to become Th2-like cells. TCF-7 may also function as a transcriptional repressor of certain target genes including CTNNB1 and TCF7L2 . The S33-966 antibody crossreacts with human TCF-7.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|TCF7; Transcription factor 7; TCF-1; TCF1; T-cell factor 1|
|Mouse TCF-7 Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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