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TCF-7/TCF-1 Mouse, PE, Clone: S33-966, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 564217
Description
The S33-966 monoclonal antibody specifically binds to TCF-7 (Transcription factor 7) which is also known as TCF-1 (T-cell factor 1). TCF-7 is a member of the High Mobility Group (HMG) DNA binding protein family of transcription factors. TCF-7 is expressed in thymocytes, T lymphocytes and proliferating epithelial cells. TCF-7 is expressed in the earliest T cell precursors and serves as a critical transcriptional regulator that is involved in the differentiation of thymocytes to become mature T lymphocytes. TCF-7 is necessary for the survival of immature CD4+CD8+ thymocytes. TCF-7 can also promote the differentiation of mature peripheral T cells to become Th2-like cells. TCF-7 may also function as a transcriptional repressor of certain target genes including CTNNB1 and TCF7L2 . The S33-966 antibody crossreacts with human TCF-7.
Specifications
| TCF-7/TCF-1 | |
| Monoclonal | |
| 0.2mg/mL | |
| TCF7; Transcription factor 7; TCF-1; TCF1; T-cell factor 1 | |
| Mouse TCF-7 Recombinant Protein | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| S33-966 | |
| PE | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG1 κ |
Safety and Handling
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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