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MilliporeSigma™ anti-TCR beta chain, FITC, Clone: H57-597,

Catalog No. MABF1455MI Shop All MilliporeSigma Products
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MABF1455MI 100 μg
MABF1454MI 25 μg
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Description

Armenian Hamster Monoclonal Antibody

Specifically detects TCR beta chain Clone: H57-597 in Mouse samples, and it is validated for Flow Cytometry

The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCR beta chain
Applications Flow Cytometry
Classification Monoclonal
Clone H57-597
Conjugate FITC
Formulation Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Accession No. P0C6B2
Gene Symbols Ptcra
Host Species Armenian Hamster
Immunogen Proprietary immunogen
Purification Method Purified by size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage 2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Form Purified
Isotype IgG
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For Research Use Only

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