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TEM7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520427

Catalog No. PIPA520427


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Description

Description

A suggested positive control is human liver tissue lysate. PA5-20427 can be used with blocking peptide PEP-0544.

Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and maligt colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist; these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of maligt colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
Specifications

Specifications

TEM7
Polyclonal
Unconjugated
PLXDC1
Liquid
PLXDC1
A 16 amino acid peptide from near the carboxy terminus of human TEM7.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8IUK5, Q91ZV7
TEM3, TEM7; 2410003I07Rik; plexin domain-containing protein 1; tumor endothelial marker 3; tumor endothelial marker 7
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
303505, 57125, 72324
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