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TFIIB Mouse, Unlabeled, Clone: 24, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 610462
Description
TFIIB is a ubiquitous factor required for transcription initiation by RNA polymerase II. Studies suggest that TFIIB serves as a bridge between the “TATA”-binding factor (TFIID) and RNA polymerase II during pre-initiation complex assembly and that TFIIB can be a target of acidic activators. An essential component of the machinery that transcribes protein-coding genes, the three-dimensional structure of the human TFIIB appears to consist of two direct repeats that adopt similar alpha-helical folds, conferring pseudo-twofold symmetry. An extensive, central basic surface, including an amphipathic alpha helix, is critical to the function of TFIIB as a bridge between the TBP-promoter complex and transcription factors. TFIIB has a calculated molecular weight of 33kDa and has been reported to be observed to migrate between 33-40kDa.
Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications
TFIIB | |
Monoclonal | |
250μg/mL | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
50 μg | |
Cell Biology | |
Canine, Frog, Human, Mouse, Rat |
Immunofluorescence, Immunoprecipitation, Western Blot | |
24 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
IgG2a |
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For Research Use Only.