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TFIIB Mouse, Unlabeled, Clone: 24, BD

Catalog No. BDB610462 Shop All BD Biosciences Products
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BDB610462 50 μg
BDB610463 150 μg
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Catalog No. BDB610462 Supplier BD Biosciences Supplier No. 610462

Description

Mouse Monoclonal Antibody

TFIIB is a ubiquitous factor required for transcription initiation by RNA polymerase II. Studies suggest that TFIIB serves as a bridge between the “TATA”-binding factor (TFIID) and RNA polymerase II during pre-initiation complex assembly and that TFIIB can be a target of acidic activators. An essential component of the machinery that transcribes protein-coding genes, the three-dimensional structure of the human TFIIB appears to consist of two direct repeats that adopt similar alpha-helical folds, conferring pseudo-twofold symmetry. An extensive, central basic surface, including an amphipathic alpha helix, is critical to the function of TFIIB as a bridge between the TBP-promoter complex and transcription factors. TFIIB has a calculated molecular weight of 33kDa and has been reported to be observed to migrate between 33-40kDa.

Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen TFIIB
Applications Immunofluorescence, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 24
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Frog, Human, Mouse, Rat
Isotype IgG2a
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For Research Use Only.

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