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MilliporeSigma™ anti-TGF-alpha Clone: 213-4.4,

Catalog No. GF10100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
GF10100UG 100 μg Unconjugated
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Catalog No. GF10100UG Supplier MilliporeSigma™ Supplier No. GF10100UG

Description

Mouse Monoclonal Antibody

Specifically detects TGF-α Clone: 213-4.4 in Canine, Hamster, Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Transforming growth factor-alpha (TGF-α) is an acid- and heat-stable 50 amino acid protein of 5500 MW originally found in rodents and humans. TGF-α is 33% homologous at the amino acid level to epidermal growth factor (EGF). TGF-α binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor, and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-beta. TGF-α is secreted by a variety of transformed cells and tumors, embryonic cells, and some normal adult cells. TGF-α bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TGF-α
Applications Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 213-4.4
Conjugate Unconjugated
Formulation In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Host Species Mouse
Immunogen recombinant human TGF-α (∽6kDa mature form)
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽6kDa TGF-α protein in A2058 cells or skin tissue.
Target Species Canine, Hamster, Human, Mouse, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG2a
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