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MilliporeSigma™ anti-Tiam1, Polyclonal

Catalog No. ST107050UG Shop All MilliporeSigma Products
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Quantity:
50 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ST107050UG 50 μg Unconjugated
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Catalog No. ST107050UG Supplier MilliporeSigma™ Supplier No. ST107050UG
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Description

Rabbit Polyclonal Antibody

Specifically detects Tiam1 Clone: in Human, Mouse samples, and it is validated for Immuno Blotting

Tiam1 (T-cell lymphoma invasion and metastasis 1) was originally identified by its ability to induce invasion by T-lymphoma cells when amplified. Tiam1 is a specific guanine nucleotide exchange factor (GEF) for the GTPase, Rac. By activating Rac1, Tiam1 regulates many cellular functions including actin cytoskeleton dynamics, cell proliferation, and cell survival. Tiam1 activity is regulated by its translocation to the membrane and the subsequent binding of its PH domain to phosphatidylinositol-3,4,5-triphosphate. Tiam1 is cleaved in a caspase-dependent manner in apoptotic cells, rendering it inactive as a result of an inability to translocate to the plasma membrane.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tiam1
Applications Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In Tris-Citrate/phosphate, pH 7.0-8.0.
Host Species Rabbit
Immunogen a synthetic peptide corresponding to amino acids from the C-terminal domain of human Tiam1
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽200kDa Tiam1 protein in Jurkat and NIH3T3 cells.
Target Species Human, Mouse
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG
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For Research Use Only

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