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TIF2 Mouse, Unlabeled, Clone: 29, BD

Catalog No. BDB610985 Shop All BD Biosciences Products
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150 μg
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BDB610985 150 μg
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Catalog No. BDB610985 Supplier BD Biosciences Supplier No. 610985

Description

Mouse Monoclonal Antibody

Nuclear receptors (NRs) are a family of ligand-inducible transcription factors that trigger complex events during development, differentiation, and homeostasis. They respond to the binding of steroid and thyroid hormones, retinoids, and vitamins. NRs contain an activation domain AF-1, which constitutively activates transcription. A second activation domain, AF-2, responds to ligand binding. Transcriptional interference/squelching between the AFs of steroid receptors first suggested the existence of Transcriptional Intermediary Factors (TIFs). TIFs mediate AF activity to the transcriptional machinery and chromatin template. TIF2 interacts directly with the ligand binding domains of several NRs in an agonist and AF-2-integrity-dependent manner. It has autonomous activation function, relieves interference between NRs, and has been shown to enhance AF-2 activity. TIF2 contains an NR interaction domain (NID) and two autonomous activation functions (AD1 and AD2). AD1 is identical to the TIF2 CBP interaction domain (CID). Thus, it is thought that TIF2 links NR AF2 activity and CBP via AD1 and functions as a transcriptional mediator through unknown CBP-independent mechanisms via AD2.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen TIF2
Applications Western Blot
Classification Monoclonal
Clone 29
Concentration 250μg/mL
Conjugate Unconjugated
Description Transcriptional Intermediary Factor-2
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human TIF2 aa. 959-1067
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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