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TIGIT Mouse anti-Mouse, PE, Clone: 1G9, BD

Catalog No. BDB565168 Shop All BD Biosciences Products
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BDB565168 0.1 mg
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Catalog No. BDB565168 Supplier BD Biosciences Supplier No. 565168
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Description

Mouse Monoclonal Antibody

The 1G9 monoclonal antibody specifically binds to T cell immunoreceptor with Ig and ITIM domains (TIGIT) which is also known as, V-set and transmembrane domain-containing protein 3 (Vstm3). TIGIT is a 26 kDa, type I transmembrane glycoprotein that belongs to the poliovirus receptor (PVR) family. TIGIT is expressed on activated and memory CD4+ T cells and CD8+ T cells, follicular T helper cells, regulatory T cells, and NK cells. Its ligands include the poliovirus receptor (PVR, aka, CD155), poliovirus receptor-related protein 2 (PVRL2, aka, CD112), and poliovirus receptor-related protein 3 (PVRL3, CD113). TIGIT functions as a negative regulator of T cell and NK cell responses including proliferation, cytotoxicity, and the production of proinflammatory cytokines. TIGIT-deficient mice are reportedly more susceptible to developing autoimmune diseases in certain model systems.

TRUSTED_SUSTAINABILITY

Specifications

Antigen TIGIT
Applications Flow Cytometry
Classification Monoclonal
Clone 1G9
Concentration 0.2mg/mL
Conjugate PE
Description Tigit; Vstm3; T cell immunoreceptor with Ig and ITIM domains
Formulation Aqueous buffered solution containing ≤0.09% sodium azide
Host Species Mouse
Immunogen Mouse TIGIT Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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