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TLR9 Rat anti-Human, PE, Clone: EB72-1665, BD

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BDB560425 100 Tests
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Description

Rat Monoclonal Antibody

Toll-like receptor 9 (TLR9), also designated as CD289, is a type 1 transmembrane glycoprotein (∽110-119kDa calculated molecular weights for protein isoforms) encoded by the TLR9 gene in chromosome 3. TLR9 is a member of the Toll-like receptor (TLR) family whose members play fundamental roles in pathogen recognition and activation of innate immunity. TLR9 is highly expressed by plasmacytoid dendritic cells and B cells and at lower levels in some other cell types. TLR9 is expressed predominantly in the endoplasmic reticulum. It is recruited to endosomal and lysosomal compartments upon cellular stimulation by bacterial, viral or synthetic DNA molecules that contain unmethylated CpG dinucleotide sequences. TLR9 generated signals lead to the activation of genes that express type-I interferons and proinflammatory cytokines including IL-6 and IL-12. TLR9-mediated signaling is also implicated in acquired immune responses as well as in the pathogenesis of autoimmune diseases. The eB72-1665.1 mAb recognizes the human TLR9 epitope from the peptide sequence, amino acids 273-288.

Host Species: Rat
Clone: eB72-1665
Isotype: IgG2a κ
Species Reactivity: Human

TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR9
Applications Flow Cytometry
Classification Monoclonal
Clone EB72-1665
Conjugate PE
Description CD289, toll-like receptor 9
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Rat
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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