TLT-2 (Treml2) Rat anti-Mouse, Brilliant Violet 421, Clone: MIH47, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564185
The MIH47 monoclonal antibody specifically binds to Trem-like transcript 2 protein (TLT-2) which is also known as TREML2 (Triggering receptor expressed on myeloid cells-like 2). TLT-2 is a type I transmembrane protein that belongs to the TREM family. It consists of a single extra-cellular Ig-like V-type domain, a transmembrane segment and a cytoplasmic tail and reportedly serves as a receptor for B7-H3/CD276. It is expressed on most B cells, CD8+ T cells, activated CD4+ T cells, macrophages and granulocytes and at low levels by some NK cells and dendritic cells. TLT-2 can reportedly serve costimulatory and coinhibitory functions in the immune system. TLT-2 expression is upregulated on neutrophils and macrophages in response to inflammatory conditions in vivo. TLT-2 serves as engulfment receptor for apoptotic cells and plays roles in both innate and adaptive immunity.
The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). BD Horizon BV421conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|B7-H3 receptor; Tlt2; TRML2; Trem-like transcript 2 protein; Gm750|
|Mouse TLT-2 Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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