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TLT-2 (Treml2) Rat anti-Mouse, Brilliant Violet 421, Clone: MIH47, BD

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BDB564185 50 μg
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Catalog No. BDB564185 Supplier BD Biosciences Supplier No. 564185

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Description

Rat Monoclonal Antibody

The MIH47 monoclonal antibody specifically binds to Trem-like transcript 2 protein (TLT-2) which is also known as TREML2 (Triggering receptor expressed on myeloid cells-like 2). TLT-2 is a type I transmembrane protein that belongs to the TREM family. It consists of a single extra-cellular Ig-like V-type domain, a transmembrane segment and a cytoplasmic tail and reportedly serves as a receptor for B7-H3/CD276. It is expressed on most B cells, CD8+ T cells, activated CD4+ T cells, macrophages and granulocytes and at low levels by some NK cells and dendritic cells. TLT-2 can reportedly serve costimulatory and coinhibitory functions in the immune system. TLT-2 expression is upregulated on neutrophils and macrophages in response to inflammatory conditions in vivo. TLT-2 serves as engulfment receptor for apoptotic cells and plays roles in both innate and adaptive immunity.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon™ BV421can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon™ BV421conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue™ conjugates.

TRUSTED_SUSTAINABILITY

Specifications

Antigen TLT-2 (Treml2)
Applications Flow Cytometry
Classification Monoclonal
Clone MIH47
Concentration 0.2mg/mL
Conjugate Brilliant Violet 421
Description B7-H3 receptor; Tlt2; TRML2; Trem-like transcript 2 protein; Gm750
Host Species Rat
Immunogen Mouse TLT-2 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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