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TLR4 (CD284) Mouse anti-Human, PE, Clone: TF901, BD

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100 Tests
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BDB564215 100 Tests
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Catalog No. BDB564215 Supplier BD Biosciences Supplier No. 564215
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Description

Mouse Monoclonal Antibody

The TF901 monoclonal antibody specifically binds to TLR4 (Toll-like receptor 4) which is also known as CD284. TLR4 is a 110 kDa type I transmembrane glycoprotein that belongs to the Toll-like receptor (TLR) family. TLR4 is expressed on monocytes, macrophages, granulocytes, dendritic cells and endothelial cells. TLR4 binds lipopolysaccharide (LPS) which is a major membrane component of Gram-negative bacteria. It thus acts as an innate immune recognition receptor against many pathogens. In association with MD-2, LPS binds to and signals through TLR4 receptors by MyD88-dependent and MyD88-independent pathways to induce the cellular production of proinflammatory cytokines. TF901 antibody binding is not influenced by the human TLR4 D299G/T399I polymorphism. Preincubation of TLR4-positive cells with the TF901 antibody blocks the subsequent binding of the HTA125 antibody which is also specific for human TLR4.

TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR4 (CD284)
Applications Flow Cytometry
Classification Monoclonal
Clone TF901
Conjugate PE
Description TLR4; CD284; Toll-like Receptor 4; ARMD10
Host Species Mouse
Immunogen Human TLR4 Transfected Cell Line
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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