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TLR4 (CD284) Mouse anti-Human, PE, Clone: TF901, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564215

Catalog No. BDB564215

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The TF901 monoclonal antibody specifically binds to TLR4 (Toll-like receptor 4) which is also known as CD284. TLR4 is a 110 kDa type I transmembrane glycoprotein that belongs to the Toll-like receptor (TLR) family. TLR4 is expressed on monocytes, macrophages, granulocytes, dendritic cells and endothelial cells. TLR4 binds lipopolysaccharide (LPS) which is a major membrane component of Gram-negative bacteria. It thus acts as an innate immune recognition receptor against many pathogens. In association with MD-2, LPS binds to and signals through TLR4 receptors by MyD88-dependent and MyD88-independent pathways to induce the cellular production of proinflammatory cytokines. TF901 antibody binding is not influenced by the human TLR4 D299G/T399I polymorphism. Preincubation of TLR4-positive cells with the TF901 antibody blocks the subsequent binding of the HTA125 antibody which is also specific for human TLR4.



TLR4 (CD284)
TLR4; CD284; Toll-like Receptor 4; ARMD10
Affinity Purified
Human TLR4 Transfected Cell Line
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1, κ
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