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TOM70 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520664

Catalog No. PIPA520664


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Description

Description

A suggested positive control is 293 cell lysate. PA5-20664 can be used with blocking peptide PEP-0784.

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.
Specifications

Specifications

TOM70
Polyclonal
Unconjugated
TOMM70
Liquid
TOMM70, Tomm70a
A 17 amino acid peptide near the amino terminus of human TOM70.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O94826, Q9CZW5, Q75Q39
mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; translocase of outer membrane 70 kDa subunit
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
28185, 304017, 9868
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