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Topo IIα Mouse anti-Human, Unlabeled, Clone: 31, BD

Catalog No. BDB611327 Shop All BD Biosciences Products
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BDB611327 150 μg
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Catalog No. BDB611327 Supplier BD Biosciences Supplier No. 611327
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Description

Mouse Monoclonal Antibody

Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression. These enzymes transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA. Two isoforms of DNA topoisomerase II have been identified, topo IIα and topo IIβ. These have a high degree of homology, except for some divergence in the C-terminal region. Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization. Topo IIα levels rise during late S phase and peak in G2-M, whereas topo IIβ levels remain constant throughout the cell cycle. In addition, topo IIα is expressed in proliferating cells, while topo IIβ is expressed in many tissues. The exact role of these two isoforms during cell proliferation is not known, however the differences in cellular expression implicate different physiological roles. Both isoforms may also be important targets for anticancer agents that exert cytotoxicity in proliferating cells via stabilization of a topo II-DNA complex.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Topo IIα aa. 1245-1361
Formula Weight [Chemical]: 170kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Topo IIα
Applications In vitro Assay, Western Blot
Classification Monoclonal
Clone 31
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Topo IIα aa. 1245-1361
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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