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TEP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520354

Catalog No. PIPA520354


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Description

Description

A suggested positive control is human kidney tissue lysate. PA5-20354 can be used with blocking peptide PEP-0474.

Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with maligcy. At least two isoforms of TP1 are known to exist.
Specifications

Specifications

TEP1
Polyclonal
Unconjugated
TEP1
Liquid
TEP1
A 20 amino acid peptide from near the amino terminus of human TP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q99973, P97499, O08653
TLP1, TP1, TROVE1, VAULT2, p240; TROVE domain family, member 1; p80 telomerase homolog; telomerase protein 1; telomerase protein component 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
21745, 64523, 7011
Documents
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