Invitrogen™ TRAC-1 Monoclonal Antibody (1D3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522082

Catalog No. PIMA522082

Description

Peptide Sequence: FCQRELYEDS LLDHCITHHR SERRPVFCPL CRLIPDENPS SFSGSLIRHL QVSHTLFYDD FIDFNIIEEA LIRRVLDRSL LEYVNHSNT.

TRAC-1 is a 232 amino acid protein containing an N-terminal RING-type zinc finger domain. It functions as a positive regulator in the T-cell receptor signaling pathway, thus leading to T-cell activation. It mediates ubiquitination and subsequent proteasomal degradation of target proteins. TRAC-1 is expressed in lymphoid tissues, including bone marrow, spleen, thymus as well as in other tissues. It is predominantly expressed in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.

Specifications

• Antigen: TRAC-1
• Classification: Monoclonal
• Concentration: 0.34 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q96EQ8
• Gene Symbols: RNF125
• Immunogen: RNF125 (NP_060301, 143 a.a. ~ 231 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 1D3
• Conjugate: Unconjugated
• Gene: RNF125
• Gene Alias: 4930553F04Rik; E3 ubiquitin-protein ligase RNF125; RING finger protein 125; ring finger protein 125, E3 ubiquitin protein ligase; RNF125; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TNORS; TRAC1; TRAC-1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54941
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid