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TRAIL-R1 (CD261) Mouse anti-Human, PE, Clone: S35-934, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564180

Catalog No. BDB564180

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The S35-934 monoclonal antibody specifically binds to TNF-related apoptosis inducing ligand receptor 1 (TRAIL-R1/TRAIL Receptor 1). TRAIL-R1 is also known as CD261, Death Receptor 4 (DR4) and APO2. TRAIL-R1 is a type I transmembrane protein that is encoded by TNFRSF10A (tumor necrosis factor receptor superfamily, member 10a). It serves as a receptor for TNF-related apoptosis-inducing ligand (TRAIL) which is also known as CD253 and TNFSF10. TRAIL-R1 is expressed by a variety of tumor-derived cell lines. It is generally expressed at very low levels by most leucocytes. When bound by TRAIL, TRAIL-R1 can promote recruitment and subsequent activation of caspase-8, ultimately triggering the activation of effector caspases within cells that lead to apoptosis. Many transformed cell types are susceptible to TRAIL:TRAIL-R1-mediated cell death whereas normal cells are typically resistant.



TRAIL-R1 (CD261)
TNFRSF10A; TRAIL Receptor 1; TRAIL-R1; APO2; DR4; Death receptor 4
Affinity Purified
Human TRAIL-R1 Recombinant Protein
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1, κ
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