MilliporeSigma™ anti-TRAP-1 Clone: TR-1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS1276

Catalog No. MABS1276MI

Description

Specifically detects TRAP-1 Clone: TR-1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Heat shock protein 75kDa, mitochondrial (UniProt Q12931; also known as HSP 75, TNFR-associated protein 1, TRAP-1, Tumor necrosis factor type 1 receptor-associated protein) is encoded by the TRAP1 (also known as HSP75) gene (Gene ID 10131) in human. The mammalian HSP70 family consists of the mitochondrial HSP75 (TRAP-1), the endoplasmic HSP78, the cytoplasmic HSC70 (a.k.a. HSC73 and HSP73) and its inducible counterpart HSP72 (a.k.a. HSP70). TRAP-1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis. TRAP1-deficiency results in enhanced mitochondrial respiration and fatty acid oxidation, as well as increased cellular accumulation of tricarboxylic acid cycle intermediates, ATP, and reactive oxygen species species. TRAP-1-deficient cells display suppressed glucose metabolism and strikingly enhanced invasiveness, implicating a tumor suppressor role of TRAP-1.

Specifications

• Antigen: TRAP-1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: Q12931
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: TR-1
• Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: TRAP1, HSP75
• Immunogen: Recombinant protein corresponding to human TRAP-1.
• Quantity: 100 μg
• Research Discipline: Signaling
• Gene ID (Entrez): NP_057376.2
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG2a κ

For Research Use Only